A prospective study of dietary acrylamide intake and the risk of endometrial, ovarian, and breast cancer.
نویسندگان
چکیده
BACKGROUND Acrylamide, a probable human carcinogen, was detected in various heat-treated carbohydrate-rich foods in 2002. The few epidemiologic studies done thus far have not shown a relationship with cancer. Our aim was to investigate the association between acrylamide intake and endometrial, ovarian, and breast cancer risk. METHODS The Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55-69 years. At baseline (1986), a random subcohort of 2,589 women was selected using a case cohort analysis approach for analysis. The acrylamide intake of subcohort members and cases was assessed with a food frequency questionnaire and was based on chemical analysis of all relevant Dutch foods. Subgroup analyses were done for never-smokers to eliminate the influence of smoking; an important source of acrylamide. RESULTS After 11.3 years of follow-up, 327, 300, and 1,835 cases of endometrial, ovarian, and breast cancer, respectively, were documented. Compared with the lowest quintile of acrylamide intake (mean intake, 8.9 mug/day), multivariable-adjusted hazard rate ratios (HR) for endometrial, ovarian, and breast cancer in the highest quintile (mean intake, 40.2 mug/day) were 1.29 [95% confidence interval (95% CI), 0.81-2.07; P(trend)=0.18], 1.78 (95% CI, 1.10-2.88; P(trend)=0.02), and 0.93 (95% CI, 0.73-1.19; P(trend)=0.79), respectively. For never-smokers, the corresponding HRs were 1.99 (95% CI, 1.12-3.52; P(trend)=0.03), 2.22 (95% CI, 1.20-4.08; P(trend)=0.01), and 1.10 (95% CI, 0.80-1.52; P(trend)=0.55). CONCLUSIONS We observed increased risks of postmenopausal endometrial and ovarian cancer with increasing dietary acrylamide intake, particularly among never-smokers. Risk of breast cancer was not associated with acrylamide intake.
منابع مشابه
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nloaded kground: Acrylamide is a probable human carcinogen formed during cooking of many common foods. miologic studies on acrylamide and breast cancer risk have been null; however, positive associations varian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, etrial, and ovarian cancers in a prospective cohort study. thods: We assessed acrylamide int...
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nloaded kground: Acrylamide is a probable human carcinogen formed during cooking of many common foods. miologic studies on acrylamide and breast cancer risk have been null; however, positive associations varian and endometrial cancers have been reported. We studied acrylamide intake and risk for breast, etrial, and ovarian cancers in a prospective cohort study. thods: We assessed acrylamide int...
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ورودعنوان ژورنال:
- Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
دوره 16 11 شماره
صفحات -
تاریخ انتشار 2007